Transformation of fibroblast‐like synoviocytes in rheumatoid arthritis; from a friend to foe
نویسندگان
چکیده
منابع مشابه
p53 in rheumatoid arthritis: friend or foe?
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, and apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformed-appearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated mol...
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Rheumatoid arthritis (RA) has characteristic pannus tissues, which show tumor-like growth of the synovium through chronic joint inflammation. The synovium is highly penetrated by various immune cells, and the synovial lining becomes hyperplastic due to increased numbers of macrophage-like and fibroblast-like synoviocytes. Thus, a resultant hypoxic condition stimulates the expression of inflamma...
متن کاملCommentary p53 in rheumatoid arthritis: friend or foe?
The knowledge of transcription factors and proto-oncogenes has influenced the understanding of cell regulation, cell cycle, amd apoptotic cell death in rheumatoid arthritis (RA) synovium. In addition, the development of normal synovial fibroblasts into transformedappearing aggressive synovial fibroblasts may be triggered by the lack of antiproliferative factors, such as p53, p53-associated mole...
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α-GalCer = α-galactosylceramide, MHC = major histocompatibility complex, NKT = natural killer T cell, RA = rheumatoid arthritis, TCR = T cell receptor, Th = T helper. Natural Killer T (NKT) cells have been described as T lymphocytes expressing NK receptors such as NK1.1. This lymphocyte subset consists of several subpopu-lations, each with distinct characteristics [1, 2]. Unlike conventional T ...
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Epigenetics can contribute to pathogenic mechanisms in autoimmunity, and we recently identified an imprinted DNA methylation pattern in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS), involving multiple genes in pathways that have been implicated in cell migration, matrix regulation, and immune responses (1,2). To understand when alterations in DNA methylation occur in RA and the ...
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ژورنال
عنوان ژورنال: Autoimmunity Highlights
سال: 2021
ISSN: 2038-0305,2038-3274
DOI: 10.1186/s13317-020-00145-x